Efficient Synthesis of a Novel Estrone- Talaromycin Hybrid Natural Product
- 2 October 1998
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 37 (18) , 2469-2470
- https://doi.org/10.1002/(sici)1521-3773(19981002)37:18<2469::aid-anie2469>3.0.co;2-m
Abstract
Numerous pharmacologically interesting compounds are available by the synthesis of hybrid natural products. Thus, for instance, the estrone–talaromycin hybrid 2, which is synthesized in a few steps from the estrone derivative 1 by a sequence in which a hetero-Diels–Alder reaction is the key step, exhibits notable cytotoxic activity.This publication has 0 references indexed in Scilit: