EFFECT OF EXTRACELLULAR ELECTROLYTE DEPLETION ON BRAIN ELECTROLYTE PATTERN AND ELECTROSHOCK SEIZURE THRESHOLD

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Abstract
Data are presented showing the distr. of water, Na, K, and Cl in the plasma and brains of Sprague-Dawley rats subjected to acute extracellular electrolyte depletion and subsequent replacement, and the relation of these alterations to concomitant changes in electroshock seizure threshold. Although it was not possible from the data presented to identify definitively those aspects of water and electrolyte balance which determine the reduction in electroshock seizure threshold, the following tentative conclusions are drawn: The electroshock seizure threshold is not closely correlated with total brain water or the calculated intracellular fluid volume. The electroshock seizure threshold is independent of the vol. of extracellular fluid. The electroshock seizure threshold is independent of the intracellular K concn. The electroshock seizure threshold is more closely correlated with extracellular Na and Cl concn. than with other factors examined.