Metabolism of Trimethoprim in Man and Measurement of a New Metabolite: A New Fluorescence Assay
- 1 November 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 128 (Supplement) , S580-S583
- https://doi.org/10.1093/infdis/128.supplement_3.s580
Abstract
Urinary concentrations of trimethoprim (TMP) and its metabolites were measured in eight healthy subjects after oral administration of 160 mg of TMP in two tablets of Septra® (trimethoprim-sulfamethoxazole). Improved procedures for extraction of polar metabolites and for enzymic cleavage of conjugated products were applied. The 1-oxide and conjugates of demethylated metabolites were found in substantially higher concentrations than those previously reported. A new metabolite, the 3-oxide of TMP, was identified, and urinary levels of this product were also measured.Keywords
This publication has 0 references indexed in Scilit: