Genetic variation in β-adrenergic receptors in mice: A magnesium effect determined by a single gene
- 1 October 1983
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 42 (2) , 159-168
- https://doi.org/10.1017/s0016672300021625
Abstract
SUMMARY: Genetic variation in the amount of binding of dihydroalprenolol (a potent antagonist) to hepatocyte β-adrenergic receptors has been observed among inbred strains of mice. This variation is attributed to a differential effect of magnesium on the receptors between the high and low binding strains. Evidence for a single gene controlling the magnesium effect on dihydroalprenolol binding to β-adrenergic receptors was found using recombinant inbred lines between the high and low strains. We suggest the provisional gene symbol Badm.This publication has 38 references indexed in Scilit:
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