Molecular portraits and the family tree of cancer
- 1 December 2002
- journal article
- review article
- Published by Springer Nature in Nature Genetics
- Vol. 32 (S4) , 533-540
- https://doi.org/10.1038/ng1038
Abstract
The twenty-first century heralds a new era for the biological sciences and medicine. The tools of our time are allowing us to analyze complex genomes more comprehensively than ever before. A principal technology contributing to this explosion of information is the DNA microarray, which enables us to study genome-wide expression patterns in complex biological systems. Although the potential of microarrays is yet to be fully realized, these tools have shown great promise in deciphering complex diseases such as cancer. The early results are painting a detailed portrait of cancer that illustrates the individuality of each tumor and allows familial relationships to be recognized through the identification of cell types sharing common expression patterns.Keywords
This publication has 43 references indexed in Scilit:
- Metastasis genes: A progression puzzleNature, 2002
- Gene-expression profiles predict survival of patients with lung adenocarcinomaNature Medicine, 2002
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002
- Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProceedings of the National Academy of Sciences, 2001
- Delineation of prognostic biomarkers in prostate cancerNature, 2001
- Significance analysis of microarrays applied to the ionizing radiation responseProceedings of the National Academy of Sciences, 2001
- Systematic variation in gene expression patterns in human cancer cell linesNature Genetics, 2000
- Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingNature, 2000
- The Hallmarks of CancerCell, 2000
- A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive TumorsNew England Journal of Medicine, 1989