A prospective on covalent binding and toxicity
- 1 March 1977
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 2 (4) , 849-871
- https://doi.org/10.1080/15287397709529484
Abstract
In this paper are discussed (1) the three general mechanisms by which radioisotopes may be retained in animal tissues long after labeled drugs are administered, (2) ways of differentiating these mechanisms, and (3) possible relationships between the toxic effects of drugs and their metabolism. It is emphasized, however, that studies on the disposition of drugs should be coordinated with toxicity studies in order to make the results of bioavailability and pharmacokinetic studies more meaningful in setting limits for food residues.Keywords
This publication has 20 references indexed in Scilit:
- PharmacokineticsPublished by Springer Nature ,1975
- Biochemical Mechanisms of Drug ToxicityAnnual Review of Pharmacology, 1974
- OVERVIEW OF DRUG‐PROTEIN BINDINGAnnals of the New York Academy of Sciences, 1973
- Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compoundsCellular and Molecular Life Sciences, 1972
- The Metabolic Fate of [Vinyl-I-14C]Dichlorvos in the Rat after Oral and Inhalation ExposureXenobiotica, 1971
- Mercapturic Acid ConjugationPublished by Springer Nature ,1971
- Reductive EnzymesPublished by Springer Nature ,1971
- Carcinogenic Nitroso CompoundsAdvances in Cancer Research, 1967
- Cleavage of S-(1,2-dichlorovinyl)-l-cysteine by an enzyme of bovine originArchives of Biochemistry and Biophysics, 1965
- A New Metabolite of ChloramphenicolNature, 1960