Hemorrhagic Syndrome in Chicks Fed Normal Rations Supplemented With Sulfaquinoxaline.

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Abstract
Feeding of 0.1% sulfaquinoxaline in the presence of 3 - 5% alfalfa and 5 mg menadione/lb. of feed resulted in occurrence of a hemorrhagic syndrome in chicks. Hemorrhages closely resembled those encountered in field cases of hemorrhagic disease and, in many cases were accompanied by reduced hematocrits. In some chicks blood clotting time was increased by feeding sulfaquinoxaline but in most birds clotting time was normal. The toxic effect of sulfaquinoxaline was slight in chicks fed the drug starting at day-old or at 2 weeks of age but was more pronounced in chicks fed the drug at 3, 4 or 5 weeks of age. Spontaneous recovery was observed in birds which withstood the initial weight loss and anemia produced by the drug. Dietary penicillin appeared to increase the toxicity of sulfaquinoxaline.

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