Effect of an Anabolic Steroid on Nitrogen Balance and Amino Acid Patterns after Total Hip Replacement

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Abstract
The effect of an anabolic steroid, nandrolone decanoate, on N balance and plasma and muscle amino acid concentrations was studied in patients undergoing total hip replacement and receiving daily postoperative infusions of 5% dextrose and 3.5% amino acids. An i.m. injection of 200 mg immediately after operation resulted in a N balance of -48 mg N/kg per day for the first 3 days, as compared to 102 mg N/kg per day in noninjected controls. After steroid injection there was also an attenuation of trauma-induced changes in amino acid concentrations in muscle but not in plasma. Nandrolone decanoate may act directly on muscle to reduce the protein catabolism which follows a major form of operative trauma.

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