Alkylation of Tetrazoles Using Mitsunobu Conditions
- 1 July 1996
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 26 (14) , 2687-2694
- https://doi.org/10.1080/00397919608004585
Abstract
The alkylation of tetrazoles using Mitsunobu conditions and alcohols is reported. The methodology is superior to the base-promoted reaction with alkyl halides for the installation of a secondary alkyl group because it results in higher yields and facilitates the construction of chiral centers bearing tetrazole.Keywords
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