Enzyme Immunoassay of Testosterone Using the Testosterone-Glucoamylase Complex

Abstract
A highly sensitive, reproducible method was established for enzyme-coupled immunoassay of testosterone, involving coupling of testosterone to glucoamylase (EC 3.2.1.3) with a water-soluble coupling reagent carbodiimide. No enzyme activity was lost during this coupling procedure. The sensitivity of the method was comparable to that of competitive protein binding assay.