Vero cell‐expressed Epstein‐Barr virus (EBV) gp350/220 protects marmosets from EBV challenge
- 1 February 1989
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 27 (2) , 120-123
- https://doi.org/10.1002/jmv.1890270210
Abstract
The Epstein‐Barr virus (EBV) major membrane antigen, gp350/220, was purified from expressing, genetically engineered Vero cells. The antigen, formulated either with alum or Freund's adjuvant, was inoculated into EBV infection‐susceptible marmosets. After several injections, most of the marmosets developed anti‐gp350/220 antibodies, and several exhibited virus‐neutralizing activity. The immune response elicited by the alum‐adsorbed antigen proved to be protective upon virus challenge of the inoculated animals. Protection did not correlate with the presence of neutralizing antibodies.Keywords
This publication has 17 references indexed in Scilit:
- Recombinant vaccinia virus expressing epstein‐barr virus glycoprotein gp340 protects cottontop tamarins against EB virus‐induced malignant lymphomasJournal of Medical Virology, 1988
- Expression of the Epstein-Barr virus gp350/220 gene in rodent and primate cellsJournal of Virology, 1987
- Establishment and characterization of a chronic infectious mononucleosislike syndrome in common marmosetsJournal of Medical Virology, 1986
- Protection of cottontop tamarins against Epstein–Barr virus-induced malignant lymphoma by a prototype subunit vaccineNature, 1985
- Infectious Mononucleosis-Like Response in Common Marmosets Infected with Epstein-Barr VirusThe Journal of Infectious Diseases, 1984
- A highly sensitive enzyme-linked immunosorbent assay to quantitate antibodies to Epstein-Barr virus membrane antigen gp340Journal of Virological Methods, 1984
- The Leeuwenhoek Lecture, 1983 A prototype vaccine to prevent Epstein-Barr virus-associated tumoursProceedings of the Royal Society of London. B. Biological Sciences, 1984
- Comparative immunogenicity studies on epstein‐barr virus membrane antigen (MA) gp340 with novel adjuvants in mice, rabbits, and cotton‐top tamarinsJournal of Medical Virology, 1984
- A virus-free immunogen effective against Epstein-Barr virusNature, 1979