Venoocclusive disease of the liver: development of a model for predicting fatal outcome after marrow transplantation.
- 1 September 1993
- journal article
- abstracts
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 11 (9) , 1729-1736
- https://doi.org/10.1200/jco.1993.11.9.1729
Abstract
PURPOSEHepatic venoocclusive disease (VOD) is a common complication of cytoreductive therapy for marrow transplantation. Only 25% of patients who develop VOD have severe disease. We tested the hypothesis that early clinical signs of VOD would predict which patients would recover and which would die.PATIENTS AND METHODSWe evaluated 355 consecutive patients who had transplants between August 6, 1987 and July 21, 1988 for occurrence of VOD and whether it was reversible within 100 days of transplant. Total serum bilirubin and weight gain from day -7 through day +16 posttransplant were compared among patients with no, severe, or nonsevere VOD. Logistic regression models were developed to estimate probabilities of severe VOD at each of six time intervals. The accuracy of these models was tested by applying them to 392 consecutive patients who underwent transplantation between July 22, 1988 and July 20, 1989.RESULTSAs early as day -1, bilirubin and weight gain were significantly different between patients whose ...Keywords
This publication has 0 references indexed in Scilit: