The effect of treatment with interferon-gamma on type II collagen-induced arthritis
Open Access
- 1 September 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 81 (3) , 441-445
- https://doi.org/10.1111/j.1365-2249.1990.tb05353.x
Abstract
We have investigated the effects of recombinant murine interferon-gamma (rIFN-γ) on type II collagen-induced arthritis (CA) in DBA/1 mice. Therapeutic as well as prophylactic treatment with subcutaneous rIFN-γ, at 105 U/mouse six times a week, inhibited the development of CA without any obvious side effects. The accompanying suppression of anti-CII antibody responses may partly explain the inhibition of CA by rIFN-γ. The possible role of the anti-inflammatory effect of systemic IFN-γ in the inhibition of CA is discussed.Keywords
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