Staphylococcal Delayed Hypersensitivity in Mice

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Abstract
Summary: Cell migration from splenic explants of staphylococcal hypersensitive mice was significantly inhibited (10 to 20%) when cultured in the presence of homologous antigen, while no inhibition was noted when antigen was absent. Presence of staphylococcal antigen had no inhibitory effect on cell migration from explants of normal mice. Similarly, migrations from tuberculin sensitive explants were significantly inhibited (15 to 25%) when cultured in the presence of homologous (OT) antigen; when antigen was absent no inhibition occurred. Cell migrations from normal explants were unaffected by antigen (OT). Inhibition was specific in that migration from sensitive explants was repressed with homologous antigen (migration from staphylococcal sensitive explants inhibited by staphylococcal natigen and migration from tuberculin sensitive explants inhibited by OT), while heterologous antigen had no inhibitiory effect in either explant system.

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