α-Synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication
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- 25 May 2004
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 62 (10) , 1835-1838
- https://doi.org/10.1212/01.wnl.0000127517.33208.f4
Abstract
The authors recently demonstrated that genetic triplication of the SNCA locus causes Parkinson disease. Here it is shown that SNCA triplication results in a doubling in the amount of α-synuclein protein in blood. Examination of brain tissue showed a doubling in the level of SNCA message. However, at the protein level in brain, there was a greater effect on deposition of aggregated forms into insoluble fractions than on net expression of soluble α-synuclein.Keywords
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