Effects of Stroma-Free Hemoglobin and Polyhemoglobin on Complement Activation, Blood Cells and Coagulation Factors in Rats
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Artificial Cells and Artificial Organs
- Vol. 16 (1-3) , 651-652
- https://doi.org/10.3109/10731198809132627
Abstract
Poskitt et al reported that stroma of red cell membrane induced complement activation in vitro (1). On the other hand, Wilson and Thomas (2) thought that it was hemoglobin and not the stroma which causes complement activation via the alternative pathway. Infusion of stroma-free Hb resulted in complement activation in dogs but not in other species (3). The objectives of this research are to evaluate the effects of Hb and polyHb on complement activation.Keywords
This publication has 2 references indexed in Scilit:
- Preparation and in vitro characteristics of a blood substitute based on pyridoxylated polyhemoglobinApplied Biochemistry and Biotechnology, 1984
- ACTIVATION OF THE ALTERNATE COMPLEMENT PATHWAY BY AUTOLOGOUS RED CELL STROMAThe Journal of Experimental Medicine, 1973