CIRCULATING INSULIN ANTAGONISTS IN DIABETES MELLITUS: UNTREATED DIABETICS, DIABETICS DURING INFECTIONS AND ACROMEGALICS WITH DIABETES

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Abstract
SUMMARY: Using the effect of insulin on isolated rat hemidiaphragm as an assay system, it has been possible to demonstrate a circulating insulin antagonist in some new cases of diabetes of the growth-onset type as well as during the exacerbation of diabetes secondary to infections. Three out of four acromegalics with diabetes also showed evidence of insulin antagonist, while one diabetic patient with thyrotoxicosis requiring 155 u. insulin/day had no antagonist. The antagonist present in the new diabetics and during infection exhibited some characteristics similar to the antagonist previously described during diabetic acidosis [Field & Stetten, 1956a], but different from the insulin inhibitor present during chronic insulin resistance.