RADIATION-INDUCED TUMOR REGRESSION IN CARCINOMA OF THE UTERINE CERVIX: PROGNOSTIC SIGNIFICANCE

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Abstract
A study of tumor regression in patients with carcinoma of the cervix treated by external cobalt 60 teletherapy followed by intracavitary irradiation is presented. Time of complete tumor regression is noted for the different stages. A correlation between time of complete regression and histologic picture, tumor volume, age, fractionation, interval between external and internal irradiation, and 3 year survival is discussed. Tumor volume, as determined by the stage classification, and age, were found to be related to tumor regression. Regression was faster in early stages and in patients over 50 years of age. Patients with tumors regressing completely by the end of external irradiation showed an excellent 3 year survival. Patients developing complete tumor regression during the period between external and intracavitary irradiation showed a tendency towards lower 3 year survival. A late complete tumor regression is not associated with a different prognosis than when this happens early after therapy.

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