Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
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Open Access
- 17 October 2005
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 202 (8) , 1131-1139
- https://doi.org/10.1084/jem.20050914
Abstract
Raised serum levels of interferon (IFN)-α have been observed in systemic lupus erythematosus (SLE) patients, and these levels are correlated with both disease aKeywords
This publication has 48 references indexed in Scilit:
- Is targeting Toll‐like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine‐driven inflammation?Immunological Reviews, 2004
- Inferences, questions and possibilities in Toll-like receptor signallingNature, 2004
- Toll-like receptor signallingNature Reviews Immunology, 2004
- Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB MiceThe Journal of Experimental Medicine, 2003
- Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus BloodThe Journal of Experimental Medicine, 2003
- Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2Science, 2002
- Inducing Tumor Immunity through the Selective Engagement of Activating Fcγ Receptors on Dendritic CellsThe Journal of Experimental Medicine, 2002
- Innate Immune RecognitionAnnual Review of Immunology, 2002
- Presence of cutaneous interferon-a producing cells in patients with systemic lupus erythematosusLupus, 2001
- Immune Interferon in the Circulation of Patients with Autoimmune DiseaseNew England Journal of Medicine, 1979