Engineering and Material Considerations in Islet Cell Transplantation
- 1 August 1999
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biomedical Engineering
- Vol. 1 (1) , 103-127
- https://doi.org/10.1146/annurev.bioeng.1.1.103
Abstract
▪ Abstract The successful application and optimization of cell transplantation will require quantitative engineering design and analysis of cells and materials in which relevant biological processes remain complex and incompletely defined. This report primarily reviews the engineering and material considerations in islet cell transplantation, including established biological constraints and biohybrid devices for cell delivery, as well as available barrier materials and the associated processing strategies directed at the control of solute transport, barrier permeability, and host responses at the biological–material interface. Also described are current areas of investigation with particular promise as enabling technologies for accelerating the clinical effectiveness of islet cell transplantation.Keywords
This publication has 85 references indexed in Scilit:
- CTLA4-Ig prolongs survival of microencapsulated neonatal porcine islet xenografts in diabetic nod miceCell Transplantation, 1997
- Glucose-Stimulated Genes and Prospects of Gene Therapy for Type I DiabetesEndocrine Reviews, 1997
- Transplantation of discordant xenografts: a challenge revisitedImmunology Today, 1996
- Clinical islet transplantation experience of the University of California Islet Transplant ConsortiumSurgery, 1995
- A role for CD95 ligand in preventing graft rejectionNature, 1995
- Complex Coacervate Microcapsules for Mammalian Cell Culture and Artificial Organ DevelopmentBiotechnology Progress, 1993
- Treatment of severely diabetic pancreatectomized dogs using a diffusion-based hybrid pancreasDiabetes, 1992
- SUCCESSFUL ISLET/ABDOMINAL TESTIS TRANSPLANTATION DOES NOT REQUIRE LEYDIG CELLSTransplantation, 1990
- Extended allograft survival of islets grafted into intra-abdominally placed testisDiabetes, 1984
- Implantable artificial endocrine pancreas unit used to restore normoglycaemia in the diabetic ratNature, 1976