THE EFFECT OF ADRENALECTOMY AND THYROIDECTOMY ON KETONURIA AND LIVER FAT CONTENT OF THE ALBINO RAT FOLLOWING INJECTIONS OF ANTERIOR PITUITARY EXTRACT1

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Abstract
Adrenalectomy completely suppressed the excretion of acetone bodies by the fasted albino rat following injections of anterior pituitary extract, whether the animals were maintained after operation on physiological saline or on active extracts of the adrenal cortex. The presence of cortical tissue, however, permitted the normal ketogenic response to the extract. Ablation of the adrenals also prevented fatty infiltration of the liver observed in normal rats upon injections of anterior pituitary extract. Demedullaticn of the adrenals did not prevent accumulation of liver fat in response to the same extract. Thyroidectomized rats excreted large amts. of acetone bodies following pituitary extract whether tested shortly after operation or 6 weeks later. There was no correlation between the time elapsed since removal of the gland and the ketonuria elicited. Phlorid-zin injections of normal and thyroidectomized rats produced a similar degree of ketonuria.

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