Toll-like receptors and IFN-α: partners in autoimmunity
- 1 September 2006
- journal article
- editorial
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 116 (9) , 2319-2322
- https://doi.org/10.1172/JCI29879
Abstract
Many autoimmune diseases are thought to be precipitated by viral infections. In this issue of the JCI, Lang et al. demonstrate that, in a mouse model of autoimmune hepatitis, viral infections not only trigger expansion of self-reactive T cells but also activate antigen-presenting cells through TLR stimulation (see the related article beginning on page 2456). Activated cells then secrete IFN-α and TNF-α, which trigger tissue release of chemokines that attract self-reactive CD8+ T cells, ultimately leading to liver damage.Keywords
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