Protective and Opsonic Activities of a Native, pH 4.25 Intravenous Immunoglobulin G Preparation Against Common Bacterial Pathogens
- 1 July 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 8 (Supplement) , S396-S400
- https://doi.org/10.1093/clinids/8.supplement_4.s396
Abstract
The in vitro opsonic activity of a native, pH 4.25 immunoglobulin G preparation modified for intravenous use (IGIV pH 4.25) was compared with the activities of a standard reduced and alkylated, pH 6.8 preparation (IGIV-R/A pH 6.8)and a reduced and alkylated, pH 5.25 preparation (IGIV-R/A pH 5.25) against a variety of common bacterial pathogens. In most instances the opsonic titers of IGIV pH 4.25 equaled or exceeded that of IGIV-R/A pH 6.8; IGIV-R/A pH 5.25 usually had an intermediate level of activity. The protective activity of IGIV pH 4.25 against Escherichia coli in a neonatal rat model was also greater than that of IGIV-R/A pH 6.8. Thus, the functional activity of the new IGIV pH 4.25 apparently equals or exceedsthat of standard reduced and alkylated preparations.Keywords
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