Effect of Prostaglandin l2 on Ovine Maternal and Fetal Adrenal Blood Flows

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Abstract
Fetal (n = 6) and maternal (n = 7) adrenal blood flows were measured with radioactive microspheres in chronically catheterized sheep before and 90 s after prostaglandin[PG]I2 injection. Adrenal vascular resistance is defined as the mean arterial pressure (maternal) or arteriovenous pressure difference (fetal) divided by the adrenal blood flow. Both the mother and the fetus responded with a decrease in blood pressure from 103 .+-. 5.4-64 .+-. 5.7 mm Hg and 39.0 .+-. 1.2-28.0 .+-. 1.8 mm Hg, respectively. Adrenal vascular resistance per g also decreased in the mother from 72.00 .+-. 6.65-52.60 .+-. 6.62 mm Hg/(ml/min) per g and in the fetus from 11.8 .+-. 1.0-6.1 .+-. 1.6 mm Hg/(ml/min) per g. PgI2 did not significantly change the flow per g to the maternal adrenals. The fetal adrenal flow/g doubled in response to PgI2. As the doses of PgI2 are dissimilar the magnitude of the changes cannot be compared. PgI2 caused vasodilatation in both the maternal and fetal adrenals. Fetal adrenal control blood flows were significantly (P < 0.001) greater than the maternal control adrenal blood flows.

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