Hypoxanthine-Guanine Phosphoribosyltransferase Mutant Glioma Cells: Diminished Monoamine Oxidase Activity
- 10 December 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 194 (4270) , 1171-1173
- https://doi.org/10.1126/science.996547
Abstract
A defective capability of cultured rat glioma cells to reutilize purine bases (hypoxanthine-guanine phosphoribosyltransferase deficiency) was associated with a reduced capacity to oxidatively deaminate serotonin and tryptamine. The mutant glioma cells were also more sensitive to the cytotoxic effects of serotonin than were normal cells.This publication has 19 references indexed in Scilit:
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