The Enantiomerically Pure Bicyclic b-Lactams Derived from Sugars
- 1 January 1986
- journal article
- research article
- Published by The Japan Institute of Heterocyclic Chemistry in HETEROCYCLES
- Vol. 24 (2) , 285-288
- https://doi.org/10.3987/r-1986-02-0285
Abstract
Trichloroacetyl isocyanate reacts with glycals 2 and 3 under 10 kbar pressure to give (4+2) adduct 7 or 16, .beta.-lactams 8 and 9 or 17 and 18, respectively. Treatment of the post-reaction mixtures with Florisil enabled to obtain the N-unsubstituted .beta.-lactam 10 in case of products derived from 2, and 19 in case of those derived from 3.Keywords
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