SIGNIFICANCE OF BONE-MARROW SCINTIGRAPHY IN APLASTIC-ANEMIA - CONCISE COMMUNICATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 21  (3) , 213-218
Abstract
99mTc colloid and in 111In transferrin were used in a semiquantitative scintigraphic study of bone marrow activity in 76 patients with aplastic anemia, the majority of which were severe cases. The results are compared with other known prognostic parameters and with a predictive index formulated from a prior multiparametric analysis performed in 352 cases. In 47 cases, parallel abnormality of Tc and In uptakes was noted and was well correlated with other prognostic factors. In uptake is apparently a good indicator of the severity of aplasia; extension of active erythroid tissue, demonstrated with this method, is correlated with prognosis. In 9 cases, excessive In uptake is explained by dyserythropoiesis associated with granulo- and thrombocytopenia (Fanconi''s anemia in most cases). In 20 patients, TcSC [99mTc sulfur colloid] uptake was excessive compared with that of In and with other prognostic factors. Statistically, this phenomenon carries an unfavorable prognosis, but its physiological meaning remains to be defined.