Working principles in the immune system implied by the "peptidic self" model.
- 1 May 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (10) , 3400-3404
- https://doi.org/10.1073/pnas.84.10.3400
Abstract
The hypothesis that self as well as foreign proteins are processed into peptides and presented by major histocompatibility complex antigens leads to a set of working principles that could govern cellular interactions in immune responses. In particular, "idiopeptides," derived from immunoglobulins and T-cell receptors and recognized by appropriate T cells, are expected to play an important regulatory role. We show here that these speculations fit into a consistent view of the immune system.This publication has 52 references indexed in Scilit:
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