Alterations in Enzymes Related to Adenosine 3′,5′‐Monophosphate during Compensatory Growth of Rat Lung

Publisher Website
Google Scholar
Abstract
Left pneumonectomy in rats induced growth of the right lung which was maximum 1 wk after the operation. This compensatory lung growth was accompanied by an increase in adenylate cyclase/cyclic[c]AMP phosphodiesterase activity, suggesting an increase in lung cAMP levels after pneumonectomy. Activities of cAMP-dependent protein kinase, phosphorylase and glucose 6-phosphatase were increased, suggesting the enhanced activity of the cascade system (glycogenolysis). Activities of these enzymes were maximally elevated during the first 3 days of operation and preceded the growth of contralateral lung, returning to the presurgery level on day 14. Biochemical response to pneumonectomy in rats appeared to be complete in 2 wk. Changes in the activities of cAMP-related enzymes may be important in rat lung compensatory growth.

This publication has 30 references indexed in Scilit: