Apolipoprotein E—associated risk for Alzheimer's disease in the African‐American population is genotype dependent
- 8 October 1997
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 42 (4) , 659-661
- https://doi.org/10.1002/ana.410420418
Abstract
As a part of our ongoing study on Alzheimer's disease (AD) in elderly African Americans, we obtained clinical assessment and apolipoprotein E (ApoE) genotype data on 288 individuals (including 60 with AD). The ApoE σ4 allele frequency was significantly increased in AD patients compared with controls. The age‐adjusted odds ratio (OR) for AD in σ4 homozygotes was 4.83 (95% confidence interval [CI], 1.71–13.64) compared with the σ3/σ3 genotype, but the OR for AD with the σ3/σ4 genotype did not reach significance (1.20; 95% CI, 0.58–2.45). These findings suggest that the association between ApoE σ4 and AD is weaker in African Americans than in whites.Keywords
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