Community-Acquired Methicillin-ResistantStaphylococcus aureusCarrying Panton-Valentine Leukocidin Genes: Worldwide Emergence
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Open Access
- 1 August 2003
- journal article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 9 (8) , 978-984
- https://doi.org/10.3201/eid0908.030089
Abstract
Infections caused by community-acquired (CA)-methicillin resistant Staphylococcus aureus (MRSA) have been reported worldwide. We assessed whether any common genetic markers existed among 117 CA-MRSA isolates from the United States, France, Switzerland, Australia, New Zealand, and Western Samoa by performing polymerase chain reaction for 24 virulence factors and the methicillin-resistance determinant. The genetic background of the strain was analyzed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). The CA-MRSA strains shared a type IV SCCmec cassette and the Panton-Valentine leukocidin locus, whereas the distribution of the other toxin genes was quite specific to the strains from each continent. PFGE and MLST analysis indicated distinct genetic backgrounds associated with each geographic origin, although predominantly restricted to the agr3 background. Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA.Keywords
This publication has 31 references indexed in Scilit:
- Dissemination of New Methicillin-Resistant Staphylococcus aureus Clones in the CommunityJournal of Clinical Microbiology, 2002
- Multiplex PCR Strategy for Rapid Identification of Structural Types and Variants of the mec Element in Methicillin-Resistant Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 2002
- Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patientsThe Lancet, 2002
- Relationships between Staphylococcus aureus Genetic Background, Virulence Factors, agr Groups (Alleles), and Human DiseaseInfection and Immunity, 2002
- The Evolution of Pandemic Clones of Methicillin-ResistantStaphylococcus aureus: Identification of Two Ancestral Genetic Backgrounds and the AssociatedmecElementsMicrobial Drug Resistance, 2001
- Epidemiology and Clonality of Community‐Acquired Methicillin‐ResistantStaphylococcus aureusin Minnesota, 1996–1998Clinical Infectious Diseases, 2001
- Survey of Infections Due toStaphylococcusSpecies: Frequency of Occurrence and Antimicrobial Susceptibility of Isolates Collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999Clinical Infectious Diseases, 2001
- Involvement of Panton-Valentine Leukocidin--Producing Staphylococcus aureus in Primary Skin Infections and PneumoniaClinical Infectious Diseases, 1999
- Why a National Committee?Clinical Microbiology & Infection, 1996
- Molecular cloning and sequencing of the epidermal cell differentiation inhibitor gene from Staphylococcus aureusBiochemical and Biophysical Research Communications, 1991