Intestinal IgA synthesis: regulation of front-line body defences
Top Cited Papers
- 1 January 2003
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 3 (1) , 63-72
- https://doi.org/10.1038/nri982
Abstract
Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In this review, we summarize recent advances in our understanding of the sites, mechanisms and functions of intestinal IgA synthesis in mice. On the basis of these recent findings, we propose an updated model for the induction and regulation of IgA responses in the gut. In addition, we discuss new insights into the role of IgA in the maintenance of gut homeostasis and into the reciprocal interactions between gut B cells and the bacterial flora.Keywords
This publication has 94 references indexed in Scilit:
- Critical Roles of Activation-Induced Cytidine Deaminase in the Homeostasis of Gut FloraScience, 2002
- DCs induce CD40-independent immunoglobulin class switching through BLyS and APRILNature Immunology, 2002
- Molecular Mechanism of Class Switch Recombination: Linkage with Somatic HypermutationAnnual Review of Immunology, 2002
- Sequence analysis of light chain genes from human intestinal plasma cells demonstrates that lambda genes are almost all in-frame and highly mutated and most kappa genes are highly mutatedwhen in-frame and minimally mutated when out-of-frameEuropean Journal of Immunology, 2000
- Regional specialization in the mucosal immune system: what happens in the microcompartments?Immunology Today, 1999
- Analysis of Expression of Lymphocyte Homing-Related Adhesion Molecules in ALY Mice Deficient in Lymph Nodes and Peyer's PatchesCellular Immunology, 1997
- High frequency class switching of an lgM+ B lymphoma clone CH12F3 to lgA+ cellsInternational Immunology, 1996
- The Role of Interleukin-6 in Mucosal IgA Antibody Responses in VivoScience, 1994
- Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigmCell, 1994
- Common Variable Immunodeficiency Syndrome and Nodular Lymphoid Hyperplasia in the Small IntestineEndoscopy, 1988