Inhibition of the pathogenesis of spontaneous hypertension in SHR by gonadectomy

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Abstract
Male spontaneously hypertensive rat (SHR) originated from Kyoto-Wistar (WKY) were divided into 4 groups ; intact, castration (cast) performed at 4 weeks old (W) and adrenal enucleation (enucl) at 10W, cast at 4W and enucl at 22W, and enucl at 10W and cast at 22W. This would indicate 1) enucl-adrenal in the presence or absence of gonad increases significantly blood, pressure (BP) in both SHR and WKY, 2) gonadectomy significantly retards BP in both enuci-adrenal bearing and intact SHR, 3) gonadectomy did not alter the BP in WKY. These indicates that gonadal hormone(s) play of important role in the etiology of essential hypertension.

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