Cell cycle controls: potential targets for chemical carcinogens?
- 1 December 1993
- journal article
- review article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 101 (suppl 5) , 9-14
- https://doi.org/10.1289/ehp.93101s59
Abstract
The progression of the cell cycle is controlled by the action of both positive and negative growth regulators. The key players in this activity include a family of cyclins and cyclin-dependent kinases, which are themselves regulated by other kinases and phosphatases. Maintenance of balanced cell cycle controls may be directly linked to genomic stability. Loss of the check-points involved in cell cycle control may result in unrepaired DNA damage during DNA synthesis or mitosis leading to genetic mutations and contributing to carcinogenesis.Keywords
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