Lamotrigine in Rett Syndrome

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Abstract
An elevated CSF glutamate level has recently been reported in Rett syndrome. Because the anticonvulsant effect of Lamotrigine is probably due to inhibition of glutamate release, this drug was given as an add-on drug to 4 girls with Rett syndrome. All patients responded with a seizure reduction of 50% or more and an improved well-being. A controlled study at the early stages of the syndrome could be interesting. Abbreviations RS, Rett syndrome LTG, Lamotrigine VPA, valproic acid PB, phenobarbital CLB, clobazam CBZ, carbamazepine ESM, ethosuximide VGT, vigabatrin OXC, oxcarbazepin GTCS, generalized tonic-clonic seizures

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