The Purinergic P2X7 Receptor Is Not Required for Control of Pulmonary Mycobacterium tuberculosis Infection
Open Access
- 1 May 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (5) , 3192-3195
- https://doi.org/10.1128/iai.73.5.3192-3195.2005
Abstract
The importance in vivo of P2X7 receptors in control of virulent Mycobacterium tuberculosis was examined in a low-dose aerosol infection mouse model. P2X7 −/− mice controlled infection in lungs as well as wild-type mice, suggesting that the P2X7 receptor is not required for control of pulmonary M. tuberculosis infection.Keywords
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