Effects of combinations of quinoline-containing antimalarials onPlasmodium falciparumin culture

Abstract
Combinations of mefloquine, quinine, amodiaquine, chloroquine and 3-methylchloroquine were tested against chloroquine-resistant and -sensitive strains of Plasmodium falciparum in culture. All these drugs had purely additive interactions in both strains, except for mefloquine. Combinations of mefloquine with any of the other drugs always resulted in subadditive or inhibitory action.