Oxytocin Receptors: Oxytocin Analogs, but not Prostaglandins, Compete with3H-Oxytocin for Uptake by Rat Uterus*
- 1 January 1973
- journal article
- other
- Published by The Endocrine Society in Endocrinology
- Vol. 92 (1) , 104-107
- https://doi.org/10.1210/endo-92-1-104
Abstract
Uterine pieces from rats pretreated with estrogen were incubated for 1 hr at 20 C with 3H—oxytocin and nonradioactive oxytocin or its analogs, [4–threonine]—oxytocin, [8–valine]—oxytocin, [8–lysine]—vasopressin. These substances competed with 3H—oxytocin for uptake in proportion to their known oxytocic activities. [4–Proline]— oxytocin, a relatively inactive analog, was not competitive in the dose range tested. Prostaglandins E1,E2, A1 and the tromethamine salt of F2α had no effect on the uptake of 3H—oxytocin. These results suggest that oxytocin receptors exist in the uterus and that the uterotonic activities of the prostaglandins are mediated via separate receptor sites. (Endocrinology92: 104, 1973)Keywords
This publication has 0 references indexed in Scilit: