Nocathiacins, New Thiazolyl Peptide Antibiotics from Nocardia sp. II. Isolation, Characterization, and Structure Determination.
Open Access
- 1 January 2003
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 56 (3) , 232-242
- https://doi.org/10.7164/antibiotics.56.232
Abstract
A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSn) methods, and share structural similarities to glycothiohexide-α (4).Keywords
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