Preservation of quality of life after intensity‐modulated radiotherapy for early‐stage nasopharyngeal carcinoma: Results of a prospective longitudinal study

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Abstract
Background.: Xerostomia is a ubiquitous complication after conventional radiotherapy for nasopharyngeal carcinoma (NPC) that seriously impairs patient quality of life (QOL). The effect on QOL of parotid‐sparing intensity‐modulated radiotherapy (IMRT) for early‐stage NPC was assessed prospectively.Methods.: Thirty‐two patients with T1–2,N0–1,M0 NPC received IMRT. Saliva flow was measured, and the Medical Outcomes Short Form 36 (SF‐36), European Organization for Research and Treatment of Cancer (EORTC) core, and EORTC head and neck module (QLQ‐H&N35) questionnaires were completed at baseline and 2, 6, and 12 months after IMRT.Results.: Saliva flow recovered to at least 25% of baseline in most cases after 1 year. Physical function, fatigue, and vitality were problems at 2 months and then resolved (p ≤ .002). Global health scales showed continuous improvement in QOL after treatment (p ≤ .004). Xerostomia and sticky saliva were problems 2 months after treatment; thereafter, continuous improvement occurred (p ≤ .001). Xerostomia scores correlated with general aspects of QOL (p ≤ .044).Conclusion.: IMRT for early‐stage disease preserved key aspects of QOL, and a reduction in xerostomia symptoms enhanced broader aspects of QOL. © 2006 Wiley Periodicals, Inc. Head Neck, 2006