Membrane‐bound Immunoglobulin (Ig) and In Vitro Production of Ig by Lymphoid Cells from Patients with Primary Immunodeficiencies.

Publisher Website
Google Scholar
Abstract
The presence and function of B‐lymphocytes were evaluated in ten patients with primary immunodeficiency diseases by studies of the lg‐binding characteristics of lymphocytes and assessment of in vitro synthesis of Ig by lymphoid cells from these patients. One patient with Bruton‐type agammaglobulinemia failed to show any evidence of B‐lymphocytes in peripheral blood and another showed only 3% of IgG‐bearing lymphocytes. No Ig production Could be detected in culture fluids of their lymphoid tissues. Three patients with selective IgA deficiency had normal numbers of IgA‐binding lymphocytes in their peripheral blood; however, IgA could not be detected in tissue culture fluids. In four patients with acquired (common variable) hypogammaglobulinemia, results were variable. This variability strengthens arguments for further subdividing this group of patients and perhaps suggests a means for their regrouping according to the percentage of B‐lymphocytes in the peripheral blood.