Myotrophic (Anabolic) Activity of 4-Substituted Testosterone Analogs

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Abstract
Screening in castrated rats of a group of recently synthesized steroids show that the C-4 substituted testosterone analogs possess potent myotrophic and weak androgenic activity as measured by increase in weight of levator ani muscle and ventral prostate gland, respectively. Thus daily subcutaneous injections 0.5 mg 4-chlorotestosterone acetate induce greater anabolic and lesser androgenic effects than similarly administered testosterone propionate (TP); the anabolic androgenic ratios are 0.62 for the former and 0.27 for the latter. The anabolic activity of the 4-chloro-19-nortestosterone acetate and 4-chloro-19-nortestosterone cyclopentyl propionate is equivalent to that of TP, but their effect on prostate growth is less. The anabolic/androgenic ratios are 1.16 and 2.10, respectively. Neither 4-chlorotestosterone acetate nor 4-chloro-19-nortestosterone acetate has estrogenic or corticoid activity; and only the latter, however, has progestational activity.

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