The effects of acyl chain length on the micelle properties of poly(ethylene oxide)-block-poly(N-hexylL-aspartamide)-acyl conjugates
- 1 January 2002
- journal article
- Published by Taylor & Francis in Journal of Biomaterials Science, Polymer Edition
- Vol. 13 (9) , 991-1006
- https://doi.org/10.1163/156856202760319144
Abstract
Derivatives of poly(ethylene oxide)-block-poly(β-benzyl-aspartate), 12 :25 have been prepared via aminolysis of the benzyl protecting group with 6-amino-1-hexanol, followed by subsequent acylation with acetic anhydride, hexanoic acid, lauric acid, or stearic acid. A series of amphiphilic diblock copolymers based on poly(ethylene oxide)-block-poly(N-hexyl-aspartamide)-acyl conjugates with various acyl chain lengths have been prepared. The extent of esterification was determined by 1H-NMR. Aqueous micelle solutions were prepared by a dialysis method and the polymer series was characterized as a function of the acyl chain length. Transmission electron microscopy and dynamic light scattering revealed micelle-like structures of nanoscopic dimensions (< 100 nm). Environmentally sensitive fluorescent probes were loaded into the micelles in order to study the properties of the hydrophobic microdomain and to determine the critical micelle concentration (CMC). Steady-state fluorescence measurements indicated that the relative apparent core viscosity and polarity are modulated by the relative length of the attached acyl chains, as is the CMC. Increasing the acyl chain length results in a decreased CMC and a more viscous and less polar core region. Carefully chosen chemical moieties can be introduced in order to influence the properties of the poly(L-Asp) blocks of the micelles. As a result, the micellar properties can be altered via chemical modification in order to impact several key properties relevant to drug delivery.Keywords
This publication has 23 references indexed in Scilit:
- Poly(solketal methacrylate)-block-poly(2-cinnamoyloxyethyl methacrylate)-block-poly(allyl methacrylate): Synthesis and Micelle FormationMacromolecules, 2001
- Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(ϵ-caprolactone) (PCL) amphiphilic block copolymeric nanospheresJournal of Controlled Release, 2000
- Morphogenic Effect of Solvent on Crew-Cut Aggregates of Apmphiphilic Diblock CopolymersMacromolecules, 1998
- Fluorescence methods in the study of the interactions of surfactants with polymersColloids and Surfaces A: Physicochemical and Engineering Aspects, 1996
- Preparation and Characterization of the Micelle-Forming Polymeric Drug Indomethacin-lncorporated Polyfethylene oxide)-Poly(β-benzyl L-aspartate) Block Copolymer MicellesJournal of Pharmaceutical Sciences, 1996
- Modification of Poly(methylphenylphosphazene) To Increase HydrophobicityMacromolecules, 1994
- Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugatesJournal of Controlled Release, 1994
- Micelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate)Langmuir, 1993
- INTRAMOLECULAR EXCIMER FLUORESCENCE: A NEW PROBE OF PHASE TRANSITIONS IN SYNTHETIC PHOSPHOLIPID MEMBRANESPhotochemistry and Photobiology, 1980
- Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systemsJournal of the American Chemical Society, 1977