Inhibition of Mutagenicity of Food-Derived Heterocyclic Amines by Sulphoraphene - an Isothiocyanate Isolated from Radish
- 1 February 2003
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 69 (2) , 184-186
- https://doi.org/10.1055/s-2003-37713
Abstract
The naturally derived isothiocyanate, sulphoraphene [4-isothiocyanato-(1R)-(methylsulphinyl)-1-(E)-butene], isolated from seeds of radish (Raphanus sativus L., Cruciferae) was investigated for its antigenotoxic effects against a battery of cooked food mutagens (heterocyclic amines) in the Ames Salmonella/reversion assay using Salmonella typhimurium TA98 (frame-shift mutation sensitive) and TA100 (base -pair mutation sensitive) bacterial strains in the presence of Aroclor 1254 induced rat liver S9. Results of the present in vitro anti-mutagenicity studies using the base-pair mutation sensitive strain TA100, strongly suggest that sulphoraphene is a potent inhibitor of the S9-mediated mutagenicity of all the tested heterocyclic amines (60 - 75 % inhibition at a dose of 500 nmol/plate).Keywords
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