Aldosterone blocks adrenal compensatory hypertrophy in the rat

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Abstract
Adrenal compensatory hypertrophy occurs in intact and hypophysectomized anesthetized rats as well as in rats in which endogenous ACTH is suppressed by administration of dexamethasone or of dexamethasone plus low-dose ACTH. Adrenal compensatory hypertrophy is also blocked in intact and hypophysectomized animals when aldosterone alone or the combination of aldosterone, dexamethasone and ACTH is administered using Alzet pumps. Previous reports that questioned the validity of the hypothesis that adrenal compensatory hypertrophy is controlled by the glucocorticoid-ACTH negative feedback system are supported. These results require modification of current hypotheses concerning the mechanism of adrenal compensatory hypertrophy to allow for a CNS or other effect of aldosterone.