Multi-targeting by monotherapeutic antibacterials
- 1 January 2007
- journal article
- review article
- Published by Springer Nature in Nature Reviews Drug Discovery
- Vol. 6 (1) , 41-55
- https://doi.org/10.1038/nrd2202
Abstract
Antibacterial discovery research has been driven, medically, commercially and intellectually, by the need for new therapeutics that are not subject to the resistance mechanisms that have evolved to combat previous generations of antibacterial agents. This need has often been equated with the identification and exploitation of novel targets. But efforts towards discovery and development of inhibitors of novel targets have proved frustrating. It might be that the 'good old targets' are qualitatively different from the crop of all possible novel targets. What has been learned from existing targets that can be applied to the quest for new antibacterials?Keywords
This publication has 148 references indexed in Scilit:
- The Cfr rRNA Methyltransferase Confers Resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A AntibioticsAntimicrobial Agents and Chemotherapy, 2006
- Functional, Biophysical, and Structural Bases for Antibacterial Activity of TigecyclineAntimicrobial Agents and Chemotherapy, 2006
- Genetic Changes That Correlate with Reduced Susceptibility to Daptomycin in Staphylococcus aureusAntimicrobial Agents and Chemotherapy, 2006
- Epidemiology of macrolide and/or lincosamide resistant Streptococcus pneumoniae clinical isolates with ribosomal mutationsDiagnostic Microbiology and Infectious Disease, 2004
- Erythromycin Resistance Mutations in Ribosomal Proteins L22 and L4 Perturb the Higher Order Structure of 23 S Ribosomal RNAJournal of Molecular Biology, 1999
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998
- DNA Gyrase and Topoisomerase IV on the Bacterial Chromosome: Quinolone-induced DNA CleavageJournal of Molecular Biology, 1996
- Screening of natural products for antimicrobial agentsEuropean Journal of Clinical Microbiology & Infectious Diseases, 1990
- Selective inhibition of penicillin-binding proteins and its effects on growth and architecture ofStaphylococcus aureusFEMS Microbiology Letters, 1988
- Mycobacteria possess a surprisingly small number of ribosomal RNA genes in relation to the size of their genomeBiochemical and Biophysical Research Communications, 1986