The Prevention of Sporozoite-Induced Infections of Plasmodium cathemerium in the Canary by Metachloridine

Publisher Website
Google Scholar
Abstract
The antimalarial activity of 2 metanilamide derivatives and a sulfanilamide derivative was studied in both sporozoite- and blood-induced infections of P. cathemerium in the canary. The drugs were administered orally and continuously by incorporating them in the drinking water and keeping the birds under continuous light. Metachloridine (2-metanilamido-5-chloropyrimidine) prevented sporozoite infections in 4 out of 4 birds at 275 mg./-kg./day for one day prior to and 11 days following inoculation. The conc, in the blood was 1.7 mg./100 ml. 2-Metanilamidopyrimidine at 300 mg./kg./day and the same schedule, which resulted in blood concs, of 8.8 mg./lOO ml., prevented a sporozoite infection in only 1 of 4 birds but markedly prolonged the incubation period in the other 3. The criteria for concluding that an infection was prevented were, 1) negative blood smears for 26 days subsequent to appearance of parasites in the controls and, 2) failure to produce infections with subinoculation. 2-Sulfanilamido-5-bromopyrimidine at 300 mg./kg./day for 0.5 day prior to and 4 days following inoculation (blood cone. 5.3 mg./100 ml.) prolonged the incubation period at most only 1 day. All 3 of the drugs suppressed blood-induced infections when administered for 1 day prior to and 6 days following inoculation in doses that gave blood cones, of 1.2, 14 and 4.2 mg./lOO ml. for the drugs in the order mentioned above.

This publication has 0 references indexed in Scilit: