Total Synthesis of Bistratamide D
- 15 January 1999
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 64 (3) , 826-831
- https://doi.org/10.1021/jo981664i
Abstract
The total synthesis of the macrocyclic hexapeptide bistratamide D is reported. The synthetic strategy involved assembly of enantiomerically pure oxazole, thiazole, and oxazoline segments derived from amino acids. Macrocyclization of the hexapeptidic aminooxazoline-oxazole-thiazole carboxylic acid fragment was accomplished by activation with O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU).Keywords
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