COCCIDIOIDAL GRANULOMA

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Abstract
This communication is a preliminary report dealing with initial, positive experimental results achieved during an attempt to elicit a specific allergic cutaneous reaction in patients and in experimental animals suffering from coccidioidal granuloma. My reason for this experimental investigation was the conviction that this disease is fairly widespread, but that because of its close mimicry of tuberculosis, it is frequently overlooked by the medical profession and by patients alike. This failure to recognize the disease is especially true, I believe, in systemic cases without any primary cutaneous involvement, in which the clinical syndrome of the condition may simulate tuberculosis or a malignant condition and in which no opportunity for direct microscopic and cultural study of the pus is available. Reports of three such cases came to my attention recently. In two of these, one in Los Angeles and another in Santa Monica, the diagnosis of coccidiosis was established at autopsy.

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