No association of G-463A myeloperoxidase gene polymorphism with MPO-ANCA-associated vasculitis

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Abstract
Background. The activation of neutrophils and monocytes by ANCA, resulting in the release of reactive oxygen species and proteases like myeloperoxidase (MPO), is essential to the pathogenesis of ANCA-associated vasculitis. As the A allele of the G-463A MPO gene polymorphism is associated with diminished activity of MPO, it is conceivable that the presence of this allele protects against MPO–ANCA-associated vasculitis. Methods. Allelic frequencies of the G-463A polymorphism were studied in 119 ANCA-associated vasculitis patients, 48 with MPO–ANCA and 71 with proteinase 3 (PR3)–ANCA. Results. Allelic frequencies of MPO G-463A promoter polymorphism did not differ between MPO–ANCA- and PR3–ANCA-associated vasculitis patients. Moreover, allelic distribution was similar to that of the normal population. Conclusions. The data suggest that G-463A polymorphism does not seem to contribute to either MPO–ANCA- or PR3–ANCA-associated vasculitis formation.